Hi HN,I’m Lloyd, one of two founders of RonanRx (https://ronanrx.com/). We are building a vertically integrated pharmaceutical company with software for prescribing, telehealth, compounding, manufacturing, and delivery. We are starting with GLP-1s and peptides.The path to RonanRx is fairly unconventional. During the pandemic, I built one of the largest mask manufacturing factories in the US. We could make a million masks in a day. We converted raw polypropylene pellets into finished pallets of masks.I had a background in software from my YC W10 company, so we took a software approach to building our factory. We used machine learning and computer vision to optimize production. We also vertically integrated almost everything. It worked. We built an efficient manufacturing operation and grew the business to 50 million dollars in revenue. Then people actually stopped caring about masks. Fair enough.Around the same time, I decided to try and lose the weight I had gained while building the factory. I ate nothing but chicken for six months. While this diet got some results, I plateaued. My doctor suggested tirzepatide, a GLP-1 medication.For me, losing weight was only the beginning. "Food noise" was gone. I showed less interest in other compulsive behavior. I stopped scrolling Instagram and quit biting my nails. But that was just the beginning. I was born with a congenital heart defect called aortic stenosis. My whole life doctors told me I'd need open heart surgery in my 40s (I am 45 now). After just 18 months using tirzepatide, my cardiologist’s began to think (and still thinks) my surgery could be pushed back until I am 70 or 80.This was all happening when I was deciding what to work on next. I wanted to keep working on manufacturing. I didn't want to build another product that could be replicated by a frontier model. Pharmaceutical manufacturing was the best combination of digital, physical, biological, and regulatory infrastructure I
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Last summer we faced a conundrum at my company, Tiger Data, a Postgres cloud vendor whose main business is in timeseries data. We were trying to grow our business towards emerging AI-centric workloads and wanted to provide a state-of-the-art hybrid search stack in Postgres. We'd already built pgvectorscale in house with the goal of scaling semantic search beyond pgvector's main memory limitations. We just needed a scalable ranked keyword search solution too.The problem: core Postgres doesn't provide this; the leading Postgres BM25 extension, ParadeDB, is guarded behind AGPL; developing our own extension appeared daunting. We'd need a small team of sharp engineers and 6-12 months, I figured. And we'd probably still fall short of the performance of a mature system like Parade/Tantivy.Or would we? I'd be experimenting long enough with AI-boosted development at that point to realize that with the latest tools (Claude Code + Opus) and an experienced hand (I've been working in database systems internals for 25 years now), the old time estimates pretty much go out the window.I told our CTO I thought I could solo the project in one quarter. This raised some eyebrows.It did take a little more time than that (two quarters), and we got some real help from the community (amazing!) after open-sourcing the pre-release. But I'm thrilled/exhausted today to share that pg_textsearch v1.0 is freely available via open source (Postgres license), on Tiger Data cloud, and hopefully soon, a hyperscalar near you:https://github.com/timescale/pg_textsearchIn the blog post accompanying the release, I overview the architecture and present benchmark results using MS-MARCO. To my surprise, we were not only able to meet Parade/Tantivy's query performance, but exceed it substantially, measuring a 4.7x advantage on query throughput at scale:https://www.tigerdata.com/blog/pg-textsearch-bm25-fu
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Hi HN!I recently switched from a Fedora/GNOME laptop to a MacBook Air. My old setup served me well as a portable workstation, but I’ve started traveling more while working remotely and needed something with similar performance but better battery life. The main thing I missed was a simple taskbar that shows the windows in the current workspace instead of a Dock that mixes everything together.I built boringBar so I would not have to use the Dock. It shows only the windows in the current Space, lets you switch Spaces by scrolling on the bar, and adds a desktop switcher so you can jump directly to any Space. You can also hide the system Dock, pin apps, preview windows with thumbnails, and launch apps from a searchable menu (I keep Spotlight disabled because for some reason it uses a lot of system resources on my machine).I’ve been dogfooding it for a few months now, and it finally felt polished enough to share.It’s for people who like macOS but want window management to feel a bit more like GNOME, Windows, or a traditional taskbar. It’s also for people like me who wanted an easier transition to macOS, especially now that Windows feels increasingly user-hostile.I’d love feedback on the UX, bugs, and whether this solves the same Dock/Spaces pain for anyone else.P.S. It might also appeal to people who feel nostalgic for the GNOME 2 desktop of yore. I started my Linux journey with it, and boringBar brings back some of that feeling for me.
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### Describe the project you are working on Godot C# bindings ### Describe the problem or limitation you are having in your project For the past weeks, I've been discussing with several Unity users intending to move to Godot C# regarding dealing with the C# garbage collector. The most common complaint I hear from users is that, in Unity, allocations can trigger unexpected GC spikes into the game. In Godot, we target to make all of the high performance APIs (those that intended to be called every frame) not allocate any memory, so theoretically the GC should not be a problem. Additionally, Godot starting from 4.0, uses the Microsoft CoreCLR version of .net, which also supposedly has a better garbage collector than Unity. But in all, after several discussions with Unity users, neither is enough reassurance for them, and they would really feel safer if Godot exposed a zero allocation API. ### Describe the feature / enhancement and how it helps to overcome the problem or limitation The idea of this proposal is that Godot exposes zero allocation versions of many functions in the C# API, that users can use if they desire. Technically, this could be done from the binding generator itself, without breaking compatibility, and without doing any modification to Godot itself. ### Describe how your proposal will work, with code, pseudo-code, mock-ups, and/or diagrams **WARNING** I am not familiar with C#, so take this as pseudocode. Imagine you have two functions exposed as to C#: ```C# void MyClass.SetArray( Vector2[] array); Vector2[] MyClass.GetArray(); ``` This works and is pretty and intuitive. However, it has two problems: * GC is allocated on return * Memory is copied to Godot native formats every time there is a call. The idea is to add NoAlloc versions, which can be generated directly by the binder automatically when required: ```C# void MyClass.SetArrayNoAlloc( Godot.Collections.PackedVector2Array array); void MyCl
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